AceView

AceView provides a curated, comprehensive and non-redundant sequence representation of all public mRNA sequences (mRNAs from GenBank or RefSeq, and single pass cDNA sequences from dbEST and Trace). These experimental cDNA sequences are first co-aligned on the genome then clustered into a minimal number of alternative transcript variants and grouped into genes. Using exhaustively and with high quality standards the available cDNA sequences evidences the beauty and complexity of mammals’ transcriptome, and the relative simplicity of the nematode and plant transcriptomes. Genes are classified according to their inferred coding potential; many presumably non-coding genes are discovered. Genes are named by Entrez Gene names when available, else by AceView gene names, stable from release to release. Alternative features (promoters, introns and exons, polyadenylation signals) and coding potential, including motifs, domains, and homologies are annotated in depth; tissues where expression has been observed are listed in order of representation; diseases, phenotypes, pathways, functions, localization or interactions are annotated by mining selected sources, in particular PubMed, GAD and Entrez Gene, and also by performing manual annotation, especially in the worm. In this way, both the anatomy and physiology of the experimentally cDNA supported human, mouse and nematode genes are thoroughly annotated.

AceView 提供了所有公共 mRNA 序列（来自 GenBank 或 RefSeq 的 mRNA 序列，以及来自 dbEST 和 Trace 的单次 cDNA 序列）的精心策划、全面且无冗余的序列表示。这些实验性 cDNA 序列首先在基因组上进行协同对齐，然后聚类成最小数量的可变剪接转录本变体，并按基因进行分组。通过全面且高质量的标准使用可用的 cDNA 序列，见证了哺乳动物转录组的美丽与复杂性，以及线虫和植物转录组的相对简单性。基因根据其推断的编码潜力进行分类；许多推测的非编码基因被发现。当可用时，基因名称使用 Entrez Gene 名称，否则使用 AceView 基因名称，这些名称在各个版本中保持稳定。可变特征（启动子、内含子和外显子、多聚腺苷酸化信号）以及编码潜力，包括基序、结构域和同源性，均进行了深度注释；列出已观察到表达的组织的代表性顺序；通过挖掘选定的来源，特别是 PubMed、GAD 和 Entrez Gene，以及进行人工注释（特别是在线虫中），对疾病、表型、通路、功能、定位或相互作用进行了注释。以此方式，对由实验性 cDNA 支持的人类、小鼠和线虫基因的解剖学和生理学进行了彻底的注释。

搜集汇总

背景与挑战

背景概述

AceView是一个综合性基因序列数据库，专注于人类、小鼠和线虫的转录组研究，提供详细的基因注释和表达分析。该数据集由NCBI维护，数据开放获取，适用于生命科学和医学研究。