The development of antibiotic tolerance is believed to be a major factor in the lengthy duration of current tuberculosis therapies. In the current study, we have modeled antibiotic tolerance in vitro
Proteins displaying the highest differential upregulation factors (top 10 proteins) are indicated. The descriptions of the genes were retrieved from TubercuList (http://tuberculist.epfl.ch/).
Majority of the cells in the bacterial populations exposed to lethal concentrations of antibiotics for prolonged duration succumbs to the antibiotics’ sterilizing activity. The remaining cells survive