Supplementary Material for: Effects of bariatric surgery in individuals with PTEN Hamartoma Tumor Syndrome (PHTS): A systematic review.

The aim of this systematic review is to provide an overview of the literature on the effects of bariatric surgery in patients with obesity and PTEN (phosphatase and tensin homolog) Hamartoma Tumor Syndrome (PHTS) diagnosis. Two studies were included with a methodological quality ranging from poor to good. Both studies were case reports in young females (<35yo), massive effects on weight loss and HbA1c levels were seen. Bariatric surgery in obese patients with PHTS diagnosis results in significant decrease in weight and complete remission of Diabetes Mellitus Type 2 (DMT2). The effects on thyroid hormones, lipid levels, renal function, and psychological factors after bariatric surgery in PHTS remain unexplored. More research is needed to fully understand how bariatric surgery can take part of the preventative treatment options for PHTS patients with obesity.