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Engineering an inhibitor resistant human CSF1R variant for microglia replacement [InVivo_RNA]. Engineering an inhibitor resistant human CSF1R variant for microglia replacement [InVivo_RNA]

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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA909243
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iPSC-derived hematopoietic progenitor cells expressing either the wildtype or G795A CSF1R variant were xenotransplanted into neonatal mice and subsequently aged for two months to compare in vivo gene expression differences between the two CSF1R genotypes. Overall design: Gene expression comparisons between iPSC-derived microglia expressing either the wildtpe of G795A CSF1R variant following neonatial xenotransplantation into the murine brain
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2022-12-06
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