Genome Wide Meta-Analysis identifies new loci associated with cardiac phenotypes and uncovers a common genetic signature shared by heart function and Alzheimer’s disease

Genome-wide meta-analysis PLINK results for five echocardiographic determinations:
Left Ventricular Mass (LVM) (g), End-Diastolic Diameter of the Aortic Root (AROT) (cm), End-Diastolic LV Internal Dimension (LVID) (cm), Left Atrial Size (LAS) (cm), and LV Wall Thickness (LVWT)(cm). Datasets included in the meta-analysis comprise: the Coronary Artery Risk Development in Young Adults (CARDIA) Study , the Cardiovascular Health Study (CHS) Cohort , the Multi-Ethnic Study of Atherosclerosis (MESA) Cohort and the Framingham study.

全基因组荟萃分析PLINK结果，涉及五种超声心动图测定指标：左心室质量（LVM）（克），主动脉根部舒张末期直径（AROT）（厘米），左心室舒张末期内部直径（LVID）（厘米），左心房大小（LAS）（厘米），以及左心室壁厚度（LVWT）（厘米）。纳入荟萃分析的数据库包括：青年成人冠状动脉风险发展研究（CARDIA）项目，心血管健康研究（CHS）队列，多民族动脉粥样硬化研究（MESA）队列，以及弗明汉研究。