Rh(III)-Catalyzed Atroposelective C–H Iodination of 1‑Aryl Isoquinolines

The rhodium-catalyzed enantioselective C–H iodination of 1-aryl isoquinolines under mild conditions is disclosed. Direct C–H iodination of 1-aryl isoquinolines with N-iodosuccinimide (NIS) catalyzed by chiral CpRh(III) complexes afforded a series of axially chiral biaryl iodides in excellent yields and enantioselectivity (up to 99% yield and 97% ee). Furthermore, the atroposelective C–H bromination and chlorination reactions were also compatible. Notably, the axially chiral biaryl iodides could be easily transformed to QUINAP-type and N,N-type chiral ligands.