Reaction expressions and parameter values for the <i>in vivo</i> Dox models.
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‡A = 10−3 (L cm−3)6.1510−6 (cm2)1109 (cells/L). ¥Measured = Fold change between the resistant and sensitive cell lines (as determined by basal SOD and G6PD activity) multiplied by the parameter value for the resistant cell line. ∥The permeability constant for doxorubicin permeation is non-constant for the duration of doxorubicin treatment. See Materials and Methods/Text S1 for detailed description.
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2011-09-15
