Crystal structure of the ternary complex of GID4-PROTAC(NEP108)-BRD4(BD1).

Crystal structure of the ternary complex of GID4-PROTAC(NEP108)-BRD4(BD1). Descriptor: 2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]-~{N}-[2-[2-[[2-[4-[2-(1~{H}-indol-2-ylmethylamino)ethanoylamino]cyclohexyl]-3~{H}-benzimidazol-5-yl]oxy]ethoxy]ethyl]ethanamide, Bromodomain-containing protein 4, Glucose-induced degradation protein 4 homolog Authors: Dong, C, Yan, X, Li, Y. Deposit date: 2023-11-24 Release date: 2025-03-26 Last modified: 2025-10-08 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Design of PROTACs utilizing the E3 ligase GID4 for targeted protein degradation. Nat.Struct.Mol.Biol., 32, 2025