Average results of classification performed on the Test Set with samples that already had a MCI that developed AD or not.

All the obtained signatures perform better than the previously know ones on the blinded test set with MCI samples that developed AD or not. Interestingly, the Ray et al.'s [1] sensitivity of 75.5% was improved to 84% on the signature obtained by discarding the single features of the signature obtained by selecting features that complement the part of Gómez Ravetti and Moscato's [3] signature that passed the entropy filter after discarding samples s3, s7, s47, s66 and s77. This signature is composed by “EGF-IGFBP-2”, “IL-1-GM-CSF”, “IL-1-IL-11”, “MIP-1d-NT-3”, “PDGF-BB-VEGF-B” and “TNF--ANG-2”. As expected, since we did not have training samples that already had a MCI, the specificity was not improved.