TRPS1 mutant (R544Q) regulates epithelial to mesenchymal transition through binding to ZEB1 promoter region. TRPS1 mutant (R544Q) regulates epithelial to mesenchymal transition through binding to ZEB1 promoter region

TRPS1 was selected as a candidate for further exploring the molecular mechanism of CRC distant metastasis according to single cell seq results. As TRPS1 is a transcriptional factor mainly located in cellular nucleus , we performed Cleavage Under Targets and Tagmentation (CUT&Tag) Sequencing assay on TRPS1-WT and TRPS1-MT cells respectively to explore the whole-genome binding site of TRPS1. Overall design: Hong, Zhao