Rodriguez-Caso2006_Polyamine_Metabolism

SBML creators: Armando Reyes-Palomares * , Carlos Rodríguez-Caso +, Raul Montañez * , Marta Cascante $, Francisca Sánchez-Jiménez * , Miguel A. Medina *

* ProCel Group, Department of Molecular Biology and Biochemistry, Faculty of Sciences, Campus de Teatinos, University of Malaga and CIBER de Enfermedades Raras (CIBER-ER). + Complex Systems Lab (ICREA-UPF), Barcelona Biomedical Research Park (PRBB-GRIB). $ Department of Biochemistry and Molecular Biology, Faculty of Biology, Universitat de Barcelona.

http://asp.uma.es

Metabolic modeling of polyamine metabolism in mammals.

Rodríguez-Caso,C et al.: J Biol Chem 2006 : 281:21799-812.

The model reproduces the dynamical behavior of the polyamine metabolism in mammals. In this model there are some additions and corrections to the publication. All perturbations and analysis have produced results very close to the published experiments. The model was successfully tested on CoPaSi v.4.4 (build 26).
Parameters not included in the publication:
1. Parameters for SSAT kinetic constants:
KmAcCoA = 1.5 µM
KmCoA = 40 µM
2. Parameters for equation MAT (table 1):
Vmax_MAT = 0.45 µM/min
Km_MAT = 41 µM
Ki_MET_MAT = 50 µM
3. Erratum.: The corrected ODE for time-dependent variable Antz is:
KsANTZ*(1-1/(1+Keq*0.01*([D]+[S])))-KdANTZ*[Antz]
According to these modifications the new steady-state analysis results are:
Metabolites:
[P]= 104.681 µM
[D]= 76.7492 µM
[S]= 58.0135 µM
[SAM]= 52.327 µM
[A]= 0.0101962 µM
[aS]= 0.0245375 µM
[aD]= 0.832236 µM
Time-dependent global parameters:
[Antz] = 0.574038 µM
Vmaxodc = 1.28315 µM/min
Vmaxssat = 0.673814 µM/min
Vmaxsamdc = 0.36829 µM/min

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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.