Clinical and metabolic characteristics of Hong Kong Chinese healthy adults stratified according to the genotypes of DACH1 rs1408888.

Data are expressed as n, mean±SD or median (interquartile range). P values were calculated from linear regression adjusted for sex and age assuming an additive model. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated as (FPI ×FPG)÷22.5, and homeostasis model assessment of beta-cell function (HOMA-β) was calculated as FPI×20÷(FPG–3.5) where FPI = fasting plasma insulin and FPG = fasting plasma glucose. Beta cell function (×10−6) was determined by the formula: [insulin AUC30min (min.pmol/l)÷glucose AUC30min (min.mmol/l)] where AUC = area under curve. Insulinogenic index was calculated as (FPI during OGTT for 30 min – 0 min) ÷(FPG during OGTT for 30 min – 0 min) where OGTT = 75 gram oral glucose tolerance test.