Additional file 8 of A dynamic single cell-based framework for digital twins to prioritize disease genes and drug targets

Additional file 8. Prioritization of all identified URs. The z score indicates the activation state of an upstream regulator. The farther the activation z score is from zero, the more likely it is that the direction of differential expression of the target genes is consistent with the regulator being in either an “activated” or an “inhibited” state. The URs (columns) are presented in ranked order, from left to rights (decreasing), based on the number of cell types that each UR is predicted to regulate at different time points (|z-score| ≥ 2 and P-value < 0.05). The data is illustrated in Fig. 7D.