Supplementary materials: Meta-analysis of visual pretreatment for the prevention of emergence delirium in children undergoing ophthalmic surgery

These are peer-reviewed supplementary materials for the article 'Meta-analysis of visual pretreatment for the prevention of emergence delirium in children undergoing ophthalmic surgery' published in the Journal of Comparative Effectiveness Research.Search strategy of PubmedSearch strategy of EmbaseSearch strategy of Cochrane librarySearch strategy of CNKIObjective: To evaluate the role of visual pretreatment in preventing emergence delirium in children receiving ophthalmic surgery. Methods: Four randomized controlled trials were identified in four databases, and a meta-analysis was conducted using RevMan 5.3. Results: Themeta-analysis demonstrated a significantly lower incidence of postoperative emergence delirium (risk ratio: 0.39; 95% CI: 0.31–0.49) and propofol rescue (risk ratio: 0.29; 95% CI: 0.13–0.65) but comparable modified Yale Preoperative Anxiety Scale score (mean difference: -3.66; 95% CI: -9.96 to 2.65) and incidence of adverse events in the visual pretreatment group. Conclusion: Visual pretreatment is effective in preventing postoperative emergence delirium in children undergoing ophthalmic surgery without significant adverse effects and can also decrease the incidence of propofol rescue.