Serological autoantibody profiling of emmetropic controls and highly myopic patiens. Serological autoantibody profiling of emmetropic controls and highly myopic patiens

High myopia is a leading cause of blindness worldwide, among which pathologic myopia, characterized by typical myopic macular degeneration, is the most detrimental. However, its pathogenesis remains largely unknown. By using a protein microarray assaying more than 20,000 human proteins, we determined in this study the autoantibody profiles of highly myopic patiens and emmetropic controls. Overall design: 36 serum samples were included, 10 from emmetropic controls and 26 from highly myopic patiens. These are dual channel arrays analyzed with each channel analyzed separately.