ADO oxidises 2AET to HTAU

Cysteine metabolism to its sulfoxidation end-products is dependent upon two iron-dependent enzymes that are the only known mammalian thiol dioxygenases. These two thiol dioxygenases are cysteine dioxygenase (CDO) and 2-aminoethanethiol dioxygenase (ADO, cysteamine dioxygenase ). Both of these thiol dioxygenases are essential for hypotaurine and taurine biosynthesis. ADO adds molecular oxygen to the sulfhydryl group of 2-aminoethanethiol (2AET, cysteamine) to form the sulfinic acid hypotaurine (HTAU) (Dominy et al. 2007).

半胱氨酸代谢及其亚磺化终产物依赖于两种铁依赖性酶，这两种酶是迄今为止所知的唯一哺乳动物硫醇双加氧酶。这两种硫醇双加氧酶分别为半胱氨酸双加氧酶（CDO）和2-氨基乙硫醇双加氧酶（ADO，即巯乙胺双加氧酶）。这两种硫醇双加氧酶对于次牛磺酸和牛磺酸的生物合成至关重要。ADO将分子氧添加至2-氨基乙硫醇（2AET，即巯乙胺）的硫醇基团，从而形成亚磺酸次牛磺酸（HTAU）（Dominy等，2007年）。