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Ammonia-Promoted One-Pot Tetrazolopiperidinone Synthesis by Ugi Reaction

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NIAID Data Ecosystem2026-03-10 收录
下载链接:
https://figshare.com/articles/dataset/Ammonia-Promoted_One-Pot_Tetrazolopiperidinone_Synthesis_by_Ugi_Reaction/4736455
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Ammonia in the tetrazole Ugi variation together with α-amino acid methyl ester-derived isocyanides provides tetrazolopiperidinones in good to high yields in one pot. The scope and limitations of this reaction were investigated by performing >70 reactions. The scaffold is useful to fill high-throughput screening decks and in structure-based drug design.
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2017-03-08
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