Crystal structure of beta-secretase complexed with an amino-ethylene inhibitor
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Crystal structure of beta-secretase complexed with an amino-ethylene inhibitor Descriptor: Beta-secretase 1, N1-((2S,3S,5R)-3-AMINO-6-(4-FLUOROPHENYLAMINO)-5-METHYL-6-OXO-1-PHENYLHEXAN-2-YL)-N3,N3-DIPROPYLISOPHTHALAMIDE Authors: Yang, W, Lu, W, Lu, Y, Zhong, M, Sun, J, Thomas, A.E, Wilkinson, J.M, Fucini, R.V, Lam, M, Randal, M, Shi, X.P, Jacobs, J.W, McDowell, R.S, Gordon, E.M, Ballinger, M.D. Deposit date: 2005-12-14 Release date: 2006-01-24 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Aminoethylenes: a tetrahedral intermediate isostere yielding potent inhibitors of the aspartyl protease BACE-1. J.Med.Chem., 49, 2006
创建时间：
2005-12-14
