Key pharmacokinetic parameters of decursin (D), decursinol angelate (DA) and decursinol (DOH) in all human subjects (n = 20) receiving dietary supplement Cogni.Q orally vs. those in rats.

The human dose for D and DA was 1.6±0.3 and 1.0±0.2 (mean±SD) mg/kg, respectively. *The terminal half-life values for four subjects were considered as outliers and were excluded. **The rat data was from our previous publication [17]. By allometric scaling [27], the rat dose was 3.5 folds of the human dose. Key pharmacokinetic parameters of decursin (D), decursinol angelate (DA) and decursinol (DOH) in all human subjects (n = 20) receiving dietary supplement Cogni.Q orally vs. those in rats.