SUMOylation of RNA binding proteins

SUMOylation of RNA-binding proteins (Li et al. 2004, reviewed in Filosa et al. 2013) alters their interactions with nucleic acids and with proteins. Whereas SUMOylation of HNRNPC decreases its affinity for nucleic acid (ssDNA), SUMOylation of NOP58 is required for binding of snoRNAs. SUMOylation of HNRNPK is required for its coactivation of TP53-dependent transcription.

RNA结合蛋白的SUMO化（Li 等人，2004年，参见Filosa 等人，2013年综述）改变了其与核酸以及蛋白质的相互作用。其中，HNRNPC的SUMO化降低了其对核酸（单链DNA）的亲和力，而NOP58的SUMO化对于snoRNA的结合则是必需的。HNRNPK的SUMO化对于其协同激活TP53依赖性转录是不可或缺的。