SynGen6: Synthetic Genomic Dataset with Diverse Ancestry

SynGen6 is a synthetic genomic dataset that encompasses six distinct populations.  We utilized Principal Component Analysis (PCA) and ϵ-local differential privacy (LDP) to generate synthetic samples. We then simulated phenotype vectors associated with significant SNPs, mirroring real-world gene-disease associations. We also generated synthetic SNPs to watermark the dataset enabling verification of outsourced computations. Lastly, synthetic relatives were created to support research on kinship inference and family-based genomic analyses. The actual SynGen6 data can be created by runningour scripts in the All of Us Research Hub WorkBench. Here, we provide a toy example based on the 1000 genomes public dataset.