The alleviation effect of W89Y/E92N and Etanercept treatment on paw swelling in the rat model of CIA.

Rats were immunized with CII, and at day 18 after the first immunization, rats that showed RA symptom were subcutaneously treated with normal saline (untreated control group), 1, 3 and 9 mg/kg of Etanercept and W89Y/E92N, respectively, once per week for two consecutive weeks. Values are means±SD of ten rats for each group. Differences between groups were examined for statistical significance by using student t test. *, P<0.05, **, P<0.01 compared with the same dosage of Etanercept treatment.