scRNA-seq data for article: Kupffer cell heterogeneity contributes to hepatic resistance in visceral leishmaniasis - filtered and annotated data

Single-cell RNA-seq dataset from sorted CD11bInt, F4/80Hi, CD64+ mouse liver cells in naive or Leishmania infantum-infected animals at 42 d.p.i.. Data analyses and results are described in manuscript: "Kupffer cell heterogeneity driven by cell migration, death and replacement contributes to hepatic resistance in visceral leishmaniasis". Data are Seurat objects in RDS format. Filtered-out potential doublets, low quality cells and dying cells (excluded cells with <1000 genes detected, cells with >6000 genes detected, cells with mitochondrial gene expression > 10% and cells with <5000 transcript molecules). Data normalization, scaling and integration performed using Seurat. Full filtered dataset in "gabiKC_combined" file. Kupffer cells only in "KC.seurat" file. Identities with "Em-KC" prefix refer to resident Kupffer cells described in the publication ("res-KC").