Chromosome conformation capture in mouse embryonic Rif1 null stem cells. Chromosome conformation capture in mouse embryonic Rif1 null stem cells

Mammalian Rif1 defines the architecture of replication-timing domains interactions through the three-dimensional organization of the nuclear volume. Deletion of RIf1 in mammalian cells causes an initial alteration of three-dimensional chromatin organization which impacts first on replication timing and genome stability, but has long-term indirect repercussions also on gene expression.