SLC7A11

This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]

该基因编码一种异源寡聚、钠离子非依赖性、阴离子氨基酸转运系统的成员，该系统对半胱氨酸和谷氨酸具有高度特异性。在该系统中，标记为Xc(-)的阴离子形式半胱氨酸通过谷氨酸的交换进行转运。该蛋白已被鉴定为卡波西肉瘤相关疱疹病毒融合及进入细胞许可性的主要介导者。此外，与正常脑组织相比，原发性胶质瘤中该基因表达量的增加与通过XCT通道增加的谷氨酸分泌相关，从而导致神经元细胞死亡。 [由RefSeq提供，2011年9月]