Therapeutic radiation drives leptomeningeal dissemination of medulloblastoma [bulkRNA-seq]. Therapeutic radiation drives leptomeningeal dissemination of medulloblastoma [bulkRNA-seq]

In this study, we examine the effect of radiation on the transcriptional profile of medulloblastoma tumor cells and its microenvironment that could potentially be leading to metastatic dissemination. Overall design: Cerebellar tumors from SmoA1 and Ptc het mice treated with radiation (1Gy) or sham radiation were collected at 5h after treatment and compared to normal cerebellum from C57BL/6 mice treated with radiation (1Gy) or sham-radiated controls by bulk cell RNA sequencing