Understanding the roles of ncRNAs in tumorigenesis and metastasis would establish avenues for the identification of diagnostic and therapeutic targets. We observed that lncRNA SNHG10 and its derived S

NIAID Data Ecosystem30

CRTC2 Forms Co-condensates with YTHDF2 that Enhance Translational Efficiency of m6A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance (RNA-seq)

肝癌分子机制

mRNA翻译调控

As the third most common cause of cancer-related mortality, hepatocellular carcinoma (HCC) is a global health concern. Despite its prevalence, treatment options are limited, underscoring the need to i

NIAID Data Ecosystem20

Development of gene expression signatures in the liver cancer cells with FXR overexpression and FXR activation. Development of gene expression signatures in the liver cancer cells with FXR overexpression and FXR activation

肝癌分子机制

基因表达谱分析

To investigate the role of nuclear receptor FXR during hepatocarcinogenesis, HepG2 cels and SK-Hep-1 cells were transfected with lentiviral mediated FXR overexpressive vector or the negative control.

NIAID Data Ecosystem50

Astrocyte elevated gene-1 (AEG-1) and c-Myc cooperate to promote hepatocarcinogenesis

肝癌分子机制

基因表达分析

Double transgenic mice with hepatocyte-specific expression of AEG-1 and c-Myc show aggressive HCC compared to single transgenics. Gene expression was analyzed to understand the molecular mechanism by

NIAID Data Ecosystem30

MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer

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