Proportions of responders to the candidate typhoid vaccine M01ZH09 (Intention to Treat population).

No., number of subjects who provided samples.
A positive immune response in the ELISA assay was defined by an increase of 50% (1.5 fold change) in LPS specific serum IgA and/or an increase of 70% (1.7 fold change) in LPS specific serum IgG compared to baseline.
*44 subjects aged 11 years and above (29 subjects in the M01ZH09 group and 15 subjects in the placebo group) were eligible for the ELISPOT.
A positive ELISPOT result was defined as ≥4 IgA antibody secreting cells specific for S. Typhi LPS per 106 PBMCs. None of the subjects had a positive day 0 ELISPOT result.