Tissue-resident memory T cells drive CD103-dependent salivary gland inflammatory infiltration in primary Sjogren's syndrome

Tissue resident memory cells (Trm) are a specialized subset of T cells residing persistently and long-term within specific tissues that contribute to persistent inflammation, tissue damage, and aberrant immune responses. Expansion of Trm in the salivary gland of primary Sjogren's Syndrome (pSS) and its animal models suggests CD103 determines the tissue localization of Trm. We characterized phenotype and function of Trm and the role of CD103 in pSS. Overall design: scRNA-seq and scTCR-seq of CD45+ immune cells flow-sorted from PBMC and ST of 5 pSS donors