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Test No. 473: In Vitro Mammalian Chromosomal Aberration Test

Organisation for Economic Co-operation and Development2026-02-07 收录

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https://www.oecd.org/en/publications/test-no-473-in-vitro-mammalian-chromosomal-aberration-test_9789264264649-en.html 数据链接链接失效反馈

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资源简介：

This test identifies agents that cause structural chromosome aberrations in cultured mammalian somatic cells.

应用场景：

遗传毒理学

抗性突变

abcdeDifferences between groups having the same letter in the same column are not statistically significant (ANOVA, Tukey HSD, p>0.05). fghDifferences between groups having the same letter in the same

NIAID Data Ecosystem80

Genetic and chemicals database used for this study.

物质浓度

遗传毒理学

Concentration of chemical components are presented as means (of three repetitions) with its standard deviation. (XLSX)

NIAID Data Ecosystem60

Frequencies of micronucleated binucleated cells (BNMN) and micronuclei (MN) as well as cytokinesis block proliferation index (CBPI) values in cultured human lymphocytes which have been treated with Chios mastic oil (CMO), mitomycin-C (MMC) (0.05 μ g/ml) and their mixture.

遗传毒理学

微核试验

BN: binucleated cells; BNMN: micronucleated binucleated cells; MN: micronuclei; CBPI: Cytokinesis Block Proliferation Index; CMO: Chios Mastic Oil; MMC: Mitomycin-C; MF (‰)±se, mean frequencies (‰)±st

NIAID Data Ecosystem20

Additional file 2 of Comparison of the frequencies of ENU-induced point mutations in male germ cells and inherited germline mutations in their offspring

遗传毒理学

化学诱变剂遗传效应

Additional file 2: Supplementary Table S1. The gpt MFs in the sperm of ENU-treated gpt delta mice. Supplementaly Table S2. Mutation spectra in the offspring of control and ENU-treated mice (WGS). Supp

NIAID Data Ecosystem70

Chromosome aberration analysis.

染色体畸变检测

遗传毒理学

aThe significance of each difference between the non-treated (−Etp) and etoposide-treated (+Etp) cells was determined using Fisher's exact test.Chromosome aberration analysis.

Figshare2015-12-02 更新30

Test No. 473: In Vitro Mammalian Chromosomal Aberration Test

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