Microarray analysis of developing mouse cortex reveals regulation of ribosomal protein mRNAs throughout development

Neocortical development is spatiotemporally regulated by exogenous factors, but the mechanism regulating timed specificity of neocortical mRNA translation is unknown. We find that active mRNA translation sites (polysomes) contain ribosomal protein subsets that undergo dynamic spatiotemporal rearrangements during mouse neocortical development. Two samples of cortex total RNA each from four embryonic time points were collected.