Dynamical Modeling of Secondary Metabolism and Metabolic Switches in Streptomyces xiamenensis 318

Mangrove-derived Streptomyces xiamenensis 318, with a relatively compact genome and simpler secondary metabolism, is used as model organism in our investigation. We performed integrated studies of metabolic dynamical modeling, transcriptome level measurements, and metabolic profiling experiments on this strain. To explore the relationship between primary and secondary metabolism, the global gene expression levels of strain 318 from early stationary phase to late stationary phase were compared by RNAseq analysis at 16 hour, 24 hour, 36 hour and 72 hour after batch culture started.