Spatially resolved quantification of polymorphic transformations in tableting process for pharmaceuticals

The crystalline polymorph of an active pharmaceutical ingredient (API) is critical to its stability and effectiveness. Unfortunately, compression induced phase transformations can occur at relevant tableting pressures for several APIs and can impact its performance. XRD-CT is the only technique that can spatially resolve phase transformations within intact tablets. It will be used to study a range of tablets of various compositions compacted at different pressures to provide a deeper understanding of the location of these transformations, and to inform mitigation strategies to ensure that these transformations do not occur.