<b>Dataset: Comparative Extraction Data for LC–MS/MS Quantification of Synthetic Cannabinoids in Human Blood (2025)</b>

This dataset supports a study evaluating <b>three extraction techniques—solid-phase extraction (SPE), liquid–liquid extraction (LLE), and QuEChERS—for LC–MS/MS quantification of five synthetic cannabinoids (JWH-018, JWH-073, AM-2201, UR-144, and XMR-011) in human blood</b>.The repository includes three main components:<b>Excel File (.xlsx)</b>Contains both <b>raw and processed data</b>, including:<b>Raw chromatographic values</b>: <code>RetentionTime</code>, <code>PeakArea</code> for all analytes.<b>Calibration curves</b>: concentration vs. peak area with regression equations and R².<b>LOD and LOQ calculations</b>: derived from calibration data (σ/S method).<b>Comparative chromatograms</b>: simulated plots for SPE, LLE, and QuEChERS extractions.<b>Performance metrics</b>: Recovery %, Matrix Effect %<b>SPSS Data File (.sav)</b>Same variables formatted for direct statistical analysis.Facilitates GLM, ANOVA, and descriptive statistics replication.<b>SPSS Output File (.spv / exported tables)</b>Contains results of statistical tests.Key outputs:Tests of Between-Subjects EffectsPairwise comparisons between extraction methodsBoxplots and bar charts (generated in SPSS)