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Regulation of gene expression through genome-wide co-binding of Hoxa9 and C/EBPα in transformed HSCs

ChEBI2014-06-11 更新2026-07-21 收录

造血干细胞

转录因子共调控

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-58362 数据链接链接失效反馈

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资源简介：

Regulation of gene expression through genome-wide co-binding of Hoxa9 and C/EBPα in transformed HSCs

应用场景：

创建时间：

2014-06-11

造血干细胞

表观遗传学

Stem cells determine homeostasis and repair of many tissues and are increasingly recognized as functionally heterogeneous. To define the extent of and molecular basis for heterogeneity we overlaid fun

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Hematopoietic stem cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia [RNASeq_Cdx2_secondaryAML]

白血病发病机制

造血干细胞

The caudal-related homeobox transcription factor CDX2 is ectopically expressed in the majority of patients with acute myeloid leukemia (AML). We generated an inducible transgenic mouse model whereby C

NIAID Data Ecosystem70

Genome-wide definition of regulatory elements in hematopoietic stem cell differentiation

造血干细胞

启动子使用分析

Cap Analysis of Gene Expression (CAGE) was used to define the promoter usage in HSPC and their committed progeny.

NIAID Data Ecosystem50

Prospective identification and lineage tracing of top-level hematopoietic stem cells that sustain adult hematopoiesis

造血干细胞鉴定

造血干细胞

Hematopoietic stem cells (HSC) sustain long-term reconstitution of hematopoiesis in primary transplantation recipients. Few HSC can serially reconstitute secondary recipients, and their identity and c

NIAID Data Ecosystem80

Additional file 3 of Quantification of hematopoietic stem and progenitor cells by targeted DNA methylation analysis

DNA甲基化

造血干细胞

Additional file 3. Table S5. Table with calculation of mean beta-values and variances for selection of candidate CpGs.

DataCite Commons2025-10-29 更新70