Anatomical Site-Specific Carbohydrate Availability Impacts Streptococcus pneumoniae Virulence and Fitness during Colonization and Disease

Transcriptomic analysis of Streptococcus pneumoniae TIGR4 wildtype and it's isogenic ccpA mutant, grown in chemically defined media supplemented with physiological levels of carbohydrates to mimic the human nasopharynx and bloodstream. The goal is to examine how anatomical site-specific carbohydrate availability impacts S. pneumoniae physiology and virulence. 6 mRNA profiles of Streptococcus pneumoniae wildtype and ccpA mutant samples that were grown in chemically defined media supplemented with physiological levels of carbohydrates to mimic the human nasopharynx and bloodstream. BioProject: PRJNA781242 Funding Source: This work was supported by NIH National Institute of Allergy and Infectious Diseases (NIAID) grants AI148368, AI114800, AI156898, and AI146149 to C.J.O. and AI146149 to H.T. H.I. is supported by NIH grant T32 HL129948. The High-Field NMR facility at the University of Alabama at Birmingham was established through NIH grant S10RR026478 and is currently supported through the comprehensive cancer center (NCI grant P30 CA013148).