Boer1985 - Macrophage T cell interaction in anti-tumor response

In this paper we present a model of the macrophage
T lymphocyte interactions that generate an
anti-tumor immune response. The modseple cifies i)
induction of cytotoxic T lymphocytes, ii) antigen
presentation by macrophages, which leads to iii)
activation of helper T cells, and iv) production of
lymphoid factors, which induce a) cytotoxic macrophages,
b) T lymphocyte proliferation, and c) an
inflammation reaction. Tumor escape mechanisms
(suppression, antigenic heterogeneity) have been
deliberately omitted from the model.