Enantiospecific Formal Total Synthesis of the Tumor and GSK-3β Inhibiting Alkaloid, (−)-Agelastatin A
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https://figshare.com/articles/dataset/Enantiospecific_Formal_Total_Synthesis_of_the_Tumor_and_GSK-3_Inhibiting_Alkaloid_-Agelastatin_A/3747708
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资源简介：
An enantiospecific total synthesis of Weinreb's advanced intermediate 2 for (−)-agelastatin A has been achieved from the Hough−Richardson
aziridine 8. Noteworthy reactions in our sequence include the highly regioselective trans-diaxial ring-opening of 8 with azide ion to set up the
vicinal diamido functionality present within (−)-2 and the Grubbs−Hoveyda ring-closing metathesis (RCM) reaction that was used to construct
its cyclopentene core.
创建时间：
2016-08-20
