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Ultra-Rare Quartet Fracture Class and Unique Reference-Backed Displaced Appendage in a Computational Longevity Discovery Pipeline (Trinity Claims #60-#61, 2026-03-19)

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Zenodo2026-03-19 更新2026-06-05 收录
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This version fixes a new cohesive milestone from the Trinity longevity-discovery pipeline. Claim #60 shows that the strong tri-core plus partial-plus-veto outsider geometry is an ultra-rare quartet fracture class in the evaluable huMAP3 quartet universe: 9 of 1068 quartets. Claim #61 shows that only one of those rare fractures is reference-backed by both an exact same-core triad and a stable same-core replacement quartet: the TOP3A/RMI2/CCDC69/PITRM1 scaffold, with RMI1 as the stable replacement outsider. This version also includes a wet-lab differential falsification package centered on PITRM1 versus RMI1 with the TOP3A/RMI2/CCDC69 core held fixed. This is a computational discovery package and not a completed causal validation study.

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2026-03-19
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