The expression profiles of human lymphoma H9 cells after exposure to doxorubicin

doxorubicin is commonly used for hematological malignancies. Since some of PTCL patients resistance to dox and die due to refractory disease or relapse, enhanced knowledge about drug response mechanisms is required to improve treatment outcome. we found an increased expression of HDAC3 in T lymphoma H9 cells following dox exprosure, we compared the gene expression profiles of H9 cells pre/post treated with doxorubicin to explore the potential mechanism of the high expression of HDAC3 To analyze the differential genes and pathways in H9 cells exposed to doxorubicin, we treated cells with doxorubicin for 6 hour,we then performed gene expression profiling analysis use data obtained from RNA-seq of doxorubicin-treated H9 cells and untreated H9 cells