VGLL1 drives therapy resistance in estrogen receptor positive breast cancer [RNA-Seq 3]
收藏NIAID Data Ecosystem2026-05-01 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE216528
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资源简介：
To investigate the function of VGLL1 in breast cancer and its role in the resistance to endocrine therapies we generated stable MCF7 cells overexpressing VGLL1 using CRISPR/Cas9 Synergistic Activation Mediator (SAM) method (MCF7 ActCas9-VGLL1 cells). MCF7 ActCas9-VGLL1 cells were also cultured in the presence of fulvestrant 100nmM or 1µM to develop fulvestrant resistant cells (MCF7 ActCas9-VGLL1-FULVR) and RNA-seq was performed in the different cell lines. Comparative gene expression profiling analysis of RNA-seq data for MCF7 ActCas9-VGLL1 cells, MCF7 ActCas9-VGLL1-FULVR cells and the parental MCF7 cells (3 replicates per cell line)
创建时间：
2024-02-10
