Gold(I) Bis(1,2,3-triazol-5-ylidene) Complexes as Promising Selective Anticancer Compounds
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https://figshare.com/articles/dataset/Gold_I_Bis_1_2_3-triazol-5-ylidene_Complexes_as_Promising_Selective_Anticancer_Compounds/16840472
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资源简介：
The
synthesis and antiproliferative activity of Mes- and iPr-substituted
gold(I) bis(1,2,3-triazol-5-ylidene) complexes in various cancer cell
lines are reported, showing nanomolar IC50 values of 50
nM (lymphoma cells) and 500 nM (leukemia cells), respectively (Mes
< iPr). The compounds exclusively induce apoptosis (50 nM to 5
μM) instead of necrosis in common malignant blood cells (leukemia
cells) and do not affect non-malignant leucocytes. Remarkably, the
complexes not only overcome resistances against the well-established
cytostatic etoposide, cytarabine, daunorubicin, and cisplatin but
also promote a synergistic effect of up to 182% when used with daunorubicin.
The present results demonstrate that gold(I) bis(1,2,3-triazol-5-ylidene)
complexes are highly promising and easily modifiable anticancer metallodrugs.
创建时间：
2021-10-20
