Enantioselective Oxidative Coupling of Carboxylic Acids to α‑Branched Aldehydes
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https://figshare.com/articles/dataset/Enantioselective_Oxidative_Coupling_of_Carboxylic_Acids_to_Branched_Aldehydes/7133891
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资源简介：
A new reactivity in organocatalysis
is proposed to account for
the coupling of carboxylic acids to α-branched aldehydes by
combining primary amine catalysis and an oxidant. The developed methodology
is an enantioselective α-coupling of aromatic and aliphatic
carboxylic acids to α-branched aldehydes and proceeds in high
yields (up to 97%) and for most examples good enantioselectivities
(up to 92% ee). On the basis of experimental and mechanistic observations,
the role of the primary amine catalyst is discussed.
创建时间：
2018-09-26
