Environmental Toxicant Induced Epigenetic Transgenerational Inheritance of Prostate Pathology and Stromal-Epithelial Cell Epigenome and Transcriptome Alterations: Ancestral Origins of Prostate Disease

The incidence of prostate disease is increasing, and some of this increase may be attributable to ancestral exposure to environmental toxicants and epigenetic transgenerational inheritance mechanisms. The goal of the current study was to determine the effects that exposure of gestating female rats to vinclozolin has on the epigenetic transgenerational inheritance of prostate disease, and to characterize by what molecular epigenetic mechanisms this has occurred. Results indicate that there were changes in DNA methylation in both cell types.前列腺疾病的发病率正不断攀升，其中部分增长可归因于祖先暴露于环境有毒物质以及表观遗传跨代遗传（epigenetic transgenerational inheritance）机制。本研究旨在明确妊娠雌性大鼠暴露于烯菌酮（vinclozolin）对前列腺疾病的表观遗传跨代遗传所产生的影响，并阐明其背后的分子表观遗传机制。研究结果表明，两种细胞类型中均存在DNA甲基化（DNA methylation）水平的改变。