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Synthesis of Optically Active Organofluorides by Ring Opening of Oxazolidinone-Fused Aziridines

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https://figshare.com/articles/dataset/Synthesis_of_Optically_Active_Organofluorides_by_Ring_Opening_of_Oxazolidinone-Fused_Aziridines/21786775
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A general method for synthesizing optically active, primary, secondary, and tertiary organofluorides was developed. This chiral pool synthesis utilized the skeleton of arabinose to generate diastereomerically pure 2-oxazolidinone-fused aziridines, which underwent ring opening with a fluoride anion. The adducts, polyoxygenated organofluorides, were useful precursors to various fluorinated compounds, such as fluorinated amino acids.
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2022-12-28
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