Screening of angiogenesis effects for tanshinone derivatives in VRI-induced blood vessels loss zebrafish embryos.

The semi-quantitative scale for restorative blood injury rates of compounds 1–11 and three tanshinones: ○, inactive; +++++, > 80% restorative rate; ++++, 60–80%; +++, 40–60%; ++,20%–40%; +aZebrafish embryos treated with the indicated concentration of compound were dead. bZebrafish embryos treated with the indicated concentration of compound were toxic and the effect was not determined.