H5N1 with Mammalian-Adaptive Mutations (HA-Q226L, PB2-T271A) in Germany, 2024 - 2025

This dataset presents nine H5N1 influenza A virus sequences from Germany (Dec 2024 - Apr 2025) carrying mammalian-adaptive mutations HA-Q226L and PB2-T271A, extracted from NCBI surveillance data.
Includes full original metadata, mutant sequences, and epidemiological summary (host, location, date).
All files shared under CC-BY-4.0 for public health use.
This dataset provides molecular evidence of H5N1 evolution with zoonotic risk implications.
=== H5N1 Germany Surveillance Dataset Summary (v2) ===
Generated on: 2025-12-10 19:57:55
Source: NCBI Influenza Virus Resource

Total metadata records: 373
Date range: 2024-12-31 — 2025-04-14
Host distribution:
Gallus gallus: 126
Anatidae: 56
Meleagris gallopavo: 40
Branta leucopsis: 24
Mustelidae: 8
Cygnus olor: 8
Larus marinus: 8
Chroicocephalus ridibundus: 8
Buteo buteo: 8
Alopochen aegyptiaca: 8
Aves: 8
Ardea cinerea: 8
Canidae: 8
Vulpes vulpes: 8
Anser sp.: 8
Mareca penelope: 8
Branta canadensis: 8
Ciconia ciconia: 8
Anas platyrhynchos: 7

Geographic locations (NCBI format):
Germany: Germany-NI: 80
Germany: Germany-NW: 61
Germany: Germany-BY: 48
Germany: Germany-TH: 32
Germany: Germany-MV: 32
Germany: Germany-ST: 32
Germany: Germany-SH: 24
Germany: Germany-BB: 24
Germany: Germany-SN: 16
Germany: Germany-BW: 16
Germany: Germany-HE: 8

Genotypes observed:
H5N1: 373

Genomic segments:
1: 47
4: 47
6: 47
5: 47
7: 47
8: 47
2: 46
3: 45

Total sequences in FASTA: 373
Sequence length range: 225 – 2330 nt
Putative segments (from headers):
Segment 1: 47
Segment 2: 46
Segment 3: 45
Segment 4: 47
Segment 5: 47
Segment 6: 47
Segment 7: 47
Segment 8: 47
Unknown segment count: 0

Accessions in metadata: 373

Accessions parsed from FASTA headers: 373

Matching accessions (intersection): 373

Study by: Tahir HB