BMP2 Signaling Activation Enhances Bone Metastases of Non-small-cell Lung Cancer

Bone metastasis is one of the most frequent metastases of NSCLC and leads to poor prognosis. It has been reported that high expression of BMP2 in NSCLC indicates poor survival, but whether BMP2 contributes to NSCLC bone metastasis remains largely unknown. We injected the Lewis lung carcinoma cells (LLCs) into tail veins of C57/BL6 mice, resulting in lung metastases and bone metastases. RNA-seq was carried for bone metastasis tissues, lung metastasis tissues and parental Lewis lung cells to analyze the transcriptome differences.