Synthesis of Pentafluorinated β‑Hydroxy Ketones
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https://figshare.com/articles/dataset/Synthesis_of_Pentafluorinated_Hydroxy_Ketones/2480734
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资源简介：
The LHMDS-promoted in situ generation of difluoroenolates
from
readily available 1-aryl and 1-alkyl 2,2,4,4,4-pentafluorobutan-1,3-dione
hydrates has been used to produce a series of pentafluorinated β-hydroxy
ketones in up to 95% yield. The reaction proceeds under mild conditions,
tolerates a wide range of functional groups, and is complete within
10 min. Reduction toward the corresponding 1,3-diol with DIBAL gives
quantitative amounts and favors the formation of the syn-isomer.
创建时间：
2016-02-20
