Generation of intestinal progenitor cells from mouse fibroblasts
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE85232
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资源简介：
We show direct conversion of mouse fibroblasts to cells that closely resemble intestinal stem cells (ISCs), through the state of fetal-type progenitor cells, called FIPCs. The induced ISCs (iISCs) exhibit self-renewal capacity and intestinal multi-lineage differentiation potential. Upon transplantation, iFIPCs and iISCs reconstitute colonic and intestinal epithelia, respectively. We conducted comparative global gene expression analyses among MEFs, iHep cells, iISC-derived budding organoids, Crypt-derived budding organoids, iFIPC-derived spherical organoids and budding organoids, and FI-derived spherical organoids and budding organoids.
创建时间：
2017-09-27
